The study, published online in the Archives of Internal Medicine, used a Markov model to compare the costs and outcomes of prescribing low-dose aspirin alone, aspirin plus a proton-pump inhibitor, or no treatment for coronary heart prevention. The researchers specifically considered the effects of each treatment on cardiovascular events and risk of upper gastrointestinal bleeding.
"This analysis supports the role of aspirin for primary prevention of cardio heart disease events in middle-aged men across a range of cardio heart disease and gastrointestinal bleeding risk levels," said Stephanie Earnshaw, Ph.D., a health economist at RTI Health Solutions, a business unit of RTI, and the paper's lead author.